One of the central disputes between Thomists and Molinists is over whether actual grace is intrinsically efficacious (Thomism) or extrinsically efficacious (Molinism). The late, great Fr. Reginald Garrigou-Lagrange explains this difference as follows:
According to Molinism, grace is efficacious only because God foresees that man will consent, whereas, for St. Thomas, “God indeed moves the will immutably, because of the efficacy of the moving power which cannot fail; but because of the nature of the will that is moved, which is indifferently disposed toward various things, it is not necessitated but remains free” (God, His Existence and His Nature, Vol. II pg. 516).